Increased Incidence of Anencephalus and Spina Bifida in Siblings of Affected Cases

Science  02 Nov 1962:
Vol. 138, Issue 3540, pp. 593-594
DOI: 10.1126/science.138.3540.593


In 139 families having a child born with anencephalus or spina bifida, 10 of 308 siblings of the affected children had malformations similar to those of the affected children. The incidence of these malformations in siblings of affected children is significantly greater than the incidence in the general population.