Effect of Glucose on the Activity of Hypothalamic "Feeding Centers"

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Science  02 Nov 1962:
Vol. 138, Issue 3540, pp. 597-598
DOI: 10.1126/science.138.3540.597


The unit activity of the neurons in the hypothalamic "satiety" and "feeding" centers and adjacent control regions was recorded before and after intravenous injection of glucose. Increase in blood glucose and arteriovenous glucose difference (glucose utilization) increases the activity of satiety center neurons and slightly decreases the activity of feeding center neurons, without producing any significant change in the activity of control regions.