Blood Group A Active Substances in Embryonated Chicken Eggs and Their Relation to Egg-Grown Virus

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Science  09 Nov 1962:
Vol. 138, Issue 3541, pp. 687-688
DOI: 10.1126/science.138.3541.687


Nondialyzable substances similar to blood group A antigens occur in White Leghorn embryos, and in partially purified egg-grown influenza virus preparations. The presence of material with group A activity in the virus itself is not proved. Commercial influenza virus vaccines which were tested contained non-dialyzable substances with group A activity. Injections of this nondialyzable material into human volunteers caused an increase in anti-human blood group A1 and A2 antibodies.