Effect of Malathion Analogs upon Resistant and Susceptible Culex Tarsalis Mosquitoes

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Science  09 Nov 1962:
Vol. 138, Issue 3541, pp. 694-695
DOI: 10.1126/science.138.3541.694


The effects of minor variations in the malathion molecule upon the resistance of Culex tarsalis have been examined. By replacing the carboethoxy group by carbomethoxy, the 60-fold resistance to malathion is abolished. The results confirm the importance of carboxyesterase action in determining susceptibility to malathion.