Electron Microscopy of Staphylococcus aureus Treated with Tetracycline

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Science  16 Nov 1962:
Vol. 138, Issue 3542, pp. 828-829
DOI: 10.1126/science.138.3542.828


After exposure to tetracycline, Staphylococcus aureus was fixed with formaldehyde and osmium tetroxide, thin-sectioned, and examined with the electron microscope. Compared with control cells, the tetracycline-treated cells had no transvers septa, were larger, had a greater electron density, and had thicker cell walls.