Purification of Gamma Globulin Fragments by Gel Filtration

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Science  04 Jan 1963:
Vol. 139, Issue 3549, pp. 53-54
DOI: 10.1126/science.139.3549.53


Treatment with papain of human 7 S gamma globulin which has specific hemagglutinating antibody activity results in 3.5 S univalent fragments contaminated by intact bivalent globulin. The technique described in this report permits separation of univalent antibody fragments from the contaminating undigested molecule.