Metabolic Deficiencies in Protozoa Induced by Thalidomide

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Science  11 Jan 1963:
Vol. 139, Issue 3550, pp. 110-111
DOI: 10.1126/science.139.3550.110


Thalidomide inhibits growth of some protozoa. This inhibition was counteracted by nicotinic acid, nicotinamide, nicotinamide adenine dinucleotide, and vitamin K1. The mechanism of toxicity may be an interference of cellular oxidation. A protozoan test system is useful for studying the potential "side actions" of drugs in higher animals and man.