Specific Immunologic Unresponsiveness to Synthetic Polypeptide Antigens

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Science  25 Jan 1963:
Vol. 139, Issue 3552, pp. 342-343
DOI: 10.1126/science.139.3552.342


The injection of two synthetic polypeptide antigens into adult rabbits treated with 6-mercaptopurine, or into newborn rabbits, resulted in immunological "unresponsiveness" to subsequent immunizations with these antigens. The "tolerant" animals were shown to be reactive toward the non-related antigen ovalbumin.