Antibodies to Genetic Types of Gamma Globulin after Multiple Transfusions

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Science  01 Feb 1963:
Vol. 139, Issue 3553, pp. 418
DOI: 10.1126/science.139.3553.418


Seventeen of 24 sera from children who had received multiple transfusions contained agglutinating antibodies against a Gm factor absent in the individual's serum gamma globulin. Each of these agglutinators was highly specific for a single Gm factor, and all proved useful as reagents for genetic typing. The accumulated evidence indicates that they resulted from genetically foreign gamma globulin introduced by transfusion.