Virus-Containing Leukocytes in Polioencephalitis

See allHide authors and affiliations

Science  08 Feb 1963:
Vol. 139, Issue 3554, pp. 499-501
DOI: 10.1126/science.139.3554.499


Crystalline aggregates of strain MM virus occur in polymorphonuclear leukocytes in association with osmiophilic granular structures which are occasionally membrane-bound. This suggests either a phagocytosis and segregation of virus by leukocytes, analogous to the disposition of bacteria by leukocytes, or a utilization of the leukocyte by the virus as a host cell for virus replication.