Reversible Agglomeration Used To Remove Dimethylsulfoxide from Large Volumes of Frozen Blood

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Science  08 Feb 1963:
Vol. 139, Issue 3554, pp. 504-505
DOI: 10.1126/science.139.3554.504


The clumping that takes place when blood is mixed with isotonic glucose is well known to the clinician. This curious phenomenon has been characterized and used to prepare blood frozen in the presence of dimethylsulfoxide for transfusion. A hypothesis is advanced to explain the mechanism of reversible agglomeration of erythrocrytes in nonelectrolyte solutions.