N-Methylmetanephrine: Excretion by Juvenile Psychotics

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Science  15 Feb 1963:
Vol. 139, Issue 3555, pp. 587-589
DOI: 10.1126/science.139.3555.587


Three out of 18 psychotic children excreted N-methylmetanephrine, a metabolite of N-methylepinephrine. It is not clear whether this tertiary amine plays a part in causing some forms of psychosis or is merely a secondary result of mental dysfunction. Urinary excretion of bufotenin and of 3,4-dimethoxyphenylethylamine, each of which has been reported elevated in some adult schizophrenics, was not unusual in these children.