Botulinus Toxin: Effect on the Central Nervous System of Man

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Science  01 Mar 1963:
Vol. 139, Issue 3557, pp. 847-848
DOI: 10.1126/science.139.3557.847


Electrical stimulation of multiple peripheral nerves, elicited "H" reflexes in a patient, 61 years old, with botulism. These reflexes are extremely suggestive of some central release or failure of inhibitory control of a monosynaptic or polysynaptic spinal reflex arc. This "central" action of botulinus toxin is similar to that suggested for tetanus toxin.