Generalized Shwartzman Reaction in the Pregnant Golden Hamster

See allHide authors and affiliations

Science  08 Mar 1963:
Vol. 139, Issue 3558, pp. 923-924
DOI: 10.1126/science.139.3558.923


A single intraperitoneal injection of colchicine regularly elicits the generalized Shwartzman phenomenon in the pregnant golden hamster. Non-pregnant hamsters are refractory both to colchicine and endotoxin. The superiority of colchicine, as opposed to foreign endotoxin, in the pregnant subject, may be attributed to the action of native endotoxin which is allowed parenteral access as a result of colchicine-induced injury to the intestinal mucosa.