Hypersensitivity to a Synthetic Polypeptide: Induction of a Delayed Reaction

See allHide authors and affiliations

Science  22 Mar 1963:
Vol. 139, Issue 3560, pp. 1222-1223
DOI: 10.1126/science.139.3560.1222


A multichain copolypeptide, p(Tyr,Glu)-pAla--pLys, induced in guinea pigs a prolonged state of delayed hypersensitivity not associated with detectable circulating antibodies. Cross reactions of the delayed type were observed with chemically related polypeptides.