Thalidomide: Effect upon Pregnancy in the Rhesus Monkey

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Science  29 Mar 1963:
Vol. 139, Issue 3561, pp. 1295-1296
DOI: 10.1126/science.139.3561.1295


Thalidomide was administered to 44 female rhesus monkeys immediately after they had mated. There were no live births from these animals, whereas there were 11 live births in 57 untreated monkeys. The results are statistically significant. The hypothesis is advanced that thalidomide killed the embryo prior to implantation.