Nonhydrolytic Pathway in Metabolism of N-Methylcarbamate Insecticides

Science  12 Apr 1963:
Vol. 140, Issue 3563, pp. 170-171
DOI: 10.1126/science.140.3563.170


Sevin (1-naphthyl N-methylcarbamate), when metabolized by rat liver microsomes and insects, yielded at least five carbamate metabolites involving modification of both the methyl group and ring. Certain of these metabolites appeared in milk when Sevin was fed to a goat. The metabolism of o-isopropoxyphenyl N-methylcarbamate by liver microsomes, insects, and plants was compared to that of Sevin.