Hereditary Globulin Factors and Immune Tolerance in Man

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Science  19 Apr 1963:
Vol. 140, Issue 3564, pp. 303-304
DOI: 10.1126/science.140.3564.303


Eight nontransfused donors of antibodies against a hereditary γ-globulin factor lacked the factor, but each donor's mother had it. The probability that this is a chance observation is .00003. A ninth donor had been transfused, and she and her mother both lacked the factor. It is assumed that each nontransfused donor's antibody was formed against his mother's γ-globulin and that immune tolerance had not been induced.