Carbon Tetrachloride Poisoning in Rats: Alteration in Ribosomes of the Liver

Science  19 Apr 1963:
Vol. 140, Issue 3564, pp. 308-310
DOI: 10.1126/science.140.3564.308


Microsomes from livers of albino rats treated with carbon tetrachloride were compared with those from normal rats with respect to their ability to incorporate amino acid. Acute carbon tetrachloride poisoning results in depressed capacity of microsomes to incorporate amino acid. From ultracentrifugal data, there is an apparent dissociation of 79S ribosomes into 54S components.