Reticulocyte Protein Synthesis: Response of Ribosome Fractions to Polyuridylic Acid

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Science  19 Apr 1963:
Vol. 140, Issue 3564, pp. 314-316
DOI: 10.1126/science.140.3564.314


Reticulocyte ribosomes with sedimentation coefficients greater than 100S ("heavy" ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and "heavy" ribosomes have similar activities. Polyuridylic acid inhibits incorporation by "heavy" ribosomes of amino acids other than phenylalanine.