Tryptophan- and Indole-Excreting Bacterial Mutants

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Science  26 Apr 1963:
Vol. 140, Issue 3565, pp. 388-389
DOI: 10.1126/science.140.3565.388


Prototrophic mutants of Escherichia coli capable of producing indole and tryptophan were obtained by selecting for resistance to antimetabolites. An anthranilic acid auxotroph grown under conditions which would derepress the tryptophan synthetase system would also accumulate substantial quantities of L-tryptophan.