Biosynthesis of Streptococcal Cell Walls: A Rhamnose Polysaccharide

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Science  26 Apr 1963:
Vol. 140, Issue 3565, pp. 400-401
DOI: 10.1126/science.140.3565.400


Protoplast membranes from Streptococcus pyogenes incorporated rhamnose into a preexisting polysaccharide when incubated with thymidine diphosphate rhamnose-C14. This polysaccharide, when extracted from the membranes, did not give a precipitin reaction with group A antisera, but could be coprecipitated with added group A polysaccharide by acetone. It is presumed to be a precursor to group specific polysaccharide of the streptococcal cell wall.