Plaque Formation in Agar by Single Antibody-Producing Cells

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Science  26 Apr 1963:
Vol. 140, Issue 3565, pp. 405
DOI: 10.1126/science.140.3565.405


Distinct plaques, each of which is due to the release of hemolysin by a single antibody-forming cell, are revealed by complement after incubation, in an agar layer, of a mixture of sheep red cells and lymphoid cells from a rabbit immunized with sheep red cells.