Vitamin E Oxidation with Alkaline Ferricyanide

Science  17 May 1963:
Vol. 140, Issue 3568, pp. 803-805
DOI: 10.1126/science.140.3568.803


Oxidation of dl-α-tocopherol or its model, 6-hydroxy-2,2,5,7,8-pentamethylchroman, with alkaline ferricyanide yields a variety of products. In addition to the known dimeric keto ether, two new products, compound A, a trimer, and compound B, an isomer of compound A, were ioslated. Ultraviolet and infrared absorption spectra and paper chromatography indicate that compound A might be identical with liver metabolite "O" which results from the addition of α-tocopherol to the diet.