Preference Aversion in Mice to Bitter Substance

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Science  17 May 1963:
Vol. 140, Issue 3568, pp. 808-809
DOI: 10.1126/science.140.3568.808


Preference-aversion functions demonstrable for sweet and salty stimuli have been found for a "bitter" substance, sucrose octaacetate, at individually specific concentrations for mice. The data support Schneirla's views correlating stimulus magnitudes and approach-withdrawal. The positive reinforcing value of this bitter substance as a weak stimulus is diminished with continuous exposure and no secondary reinforcement. Avoidance is related to intensity of stimulation rather than modality or postingestion effects.