Phosphorylase a Activity in Uterine Muscle: Stimulation by Ethylenediaminetetraacetic Acid

Science  17 May 1963:
Vol. 140, Issue 3568, pp. 811-812
DOI: 10.1126/science.140.3568.811


Injection of ethylenediaminetetraacetic acid into spayed rats or its use in phosphorylase extraction increases the activity of glycogen-phosphorylase a in uterine smooth muscle tissue. Since the total phosphorylase activity is not increased, the increase in phosphorylase a appears to result from a conversion of inactive phosphorylase b to the active form of the enzyme.