Reports

Gamma Irradiation of Polypeptides: Transformation of Amino Acids

Science  17 May 1963:
Vol. 140, Issue 3568, pp. 825-826
DOI: 10.1126/science.140.3568.825

Abstract

The formation of aspartic acid from glutamic acid, of aspartic and glutamic acids from proline, of α-amino-n-butyric acid from methionine, of aspartic acid from histidine, of dihydroxyphenylalanine from tyrosine, of tyrosine and dihydroxyphenylalanine from phenylalanine, of alanine from cysteine, and of glycine from alanine was observed when aqueous solutions of these amino acids in the form of peptides or polyamino acids were irradiated. When poly-L-glutamic acid or poly-L-proline was irradiated in the presence of C14-labeled NaHCO3, the radioactive carbon was fixed by the aspartic and the glutamic acid.

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