Tumors Induced in Hamsters by Simian Virus 40: Persistent Subviral Infection

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Science  24 May 1963:
Vol. 140, Issue 3569, pp. 889-890
DOI: 10.1126/science.140.3569.889


The cells of two hamster ependymomas, originally induced by intracerebral inoculation with simian virus 40 in newborn animals, have been serially cultured in vitro. None of the virus was detected in cell-free culture fluids or cell lysates. All cells retained their neoplastic potential when newborn hamsters were inoculated. Data suggest that viral nucleic acid is permanently present in some tumor cells.