Mammalian X-Chromosome Action: Inactivation Limited in Spread and in Region of Origin

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Science  31 May 1963:
Vol. 140, Issue 3570, pp. 976-978
DOI: 10.1126/science.140.3570.976


In its simplest form the hypothesis of the single-active-X chromosome does not explain variegated-type position effects in the mouse. Inactivity appears not to involve one entire X chromosome; furthermore, even those parts of the chromosome that can change to an inactive state spread inactivation not to the entire attached piece of autosome, but along a gradient to limited distances.