Individual Antigenic Specificity of Isolated Antibodies

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Science  14 Jun 1963:
Vol. 140, Issue 3572, pp. 1218-1219
DOI: 10.1126/science.140.3572.1218


Antisera produced against certain isolated human antibodies showed clear antigenic differences between these antibodies. Individual antigenic specificity was demonstrated for two anti-A antibodies, one anti-dextran, and one anti-levan antibody. Failure to produce specific antisera in other instances appeared to be correlated with a greater heterogeneity of the antibody population used as antigen.