Myoglobin: Inherited Structural Variation in Man

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Science  14 Jun 1963:
Vol. 140, Issue 3572, pp. 1228-1231
DOI: 10.1126/science.140.3572.1228-a


Ultrafiltrates of human myoglobin from 200 individuals were examined by starch-gel electrophoresis. Only two variants, MbAberdeen and MbAnnapolis, of the commonly occurring myoglobin Mb+ were encountered. Each variant is apparently inherited as an autosomal codominant. Heterozygotes for either mutation lack apparent muscular disease. Combined electrophoresis and chromatography of MbAnnapolis indicate a loss of arginine at a position near the C-terminal portion of the molecule.