Terminal Oxidation in the Regulation of Heme Biosynthesis

Science  21 Jun 1963:
Vol. 140, Issue 3573, pp. 1326-1327
DOI: 10.1126/science.140.3573.1326


Turnover of the tricarboxylic acid cycle and the rate of succinyl-coenzyme A formation may be important factors in the regulation of heme biosynthesis in liver homogenate. Acting as hydrogen acceptor, acetoacetate appears to have a unique role in influencing these metabolic processes.