Nitrogen Mustard: Diminution of Toxicity in Axenic Mice

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Science  28 Jun 1963:
Vol. 140, Issue 3574, pp. 1400-1401
DOI: 10.1126/science.140.3574.1400


Axenic, or germ-free, mice are more resistant to the delayed lethal effect of nitrogen mustard than normal mice. The resistance is most striking when mustard is administered at pH 2.0. The finding supports the hypothesis that intestinal bacteria play an important role in the systemic toxicity of nitrogen mustard.