Antibody to Rat Kidney: In vivo Effects of Univalent and Divalent Fragments

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Science  28 Jun 1963:
Vol. 140, Issue 3574, pp. 1406-1407
DOI: 10.1126/science.140.3574.1406


Whereas intact antibody to rat kidney (7S) produced immediate and sustained proteinuria in rats, univalent fragments (papain digests) of the antibody did not, and divalent fragments (pepsin digests) produced only transitory proteinuria. The antibody fragments differed from the intact antibody in fixing little, if any, complement in vivo which may explain why they did not cause serious renal damage.