Tumors Induced in Primates by Chicken Sarcoma Virus

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Science  28 Jun 1963:
Vol. 140, Issue 3574, pp. 1415-1416
DOI: 10.1126/science.140.3574.1415


A suspension of a variant of Rous sarcoma was injected into four adult and eight newborn rhesus monkeys. Seven newborns developed tumors, three of which were diagnosed as fibrosarcomas, in 2 to 6 weeks; none of the adults have tumors after 11 weeks. Virus was demonstrated in two of the tumors by injecting a tumor-suspension preparation into the chick wing-web where tumors subsequently appeared. To the best of our knowledge this is the first time that sarcomas have developed in primates after a virus has been injected.