Glycogen Deposition in the Liver Induced by Cortisone: Dependence on Enzyme Synthesis

Science  12 Jul 1963:
Vol. 141, Issue 3576, pp. 160-161
DOI: 10.1126/science.141.3576.160-a


The deposition of liver glycogen in starved rats given a single dose of cortisone is inhibited by puromycin and actinomycin. The former agent interferes with induced enzyme formation in general, and the latter with the cortisone-induced rise in liver enzyme levels. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins.