Teratogenic Effects of Meclizine Hydrochloride on the Rat

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Science  26 Jul 1963:
Vol. 141, Issue 3578, pp. 353-355
DOI: 10.1126/science.141.3578.353


Congenital malformations were induced in the offspring of pregnant Sprague-Dawley rats by the admninistration of relatively large doses of meclizine hydrochloride (Bonine). The critical period of gestation for administration was from the 12th to 15th day. Anomalies were produced in the tongue, palatal closure, mouth, lower jaw, vertebrae and limbs.