Crystalline Low Molecular Weight γ-Globulin from a Human Urine

Science  02 Aug 1963:
Vol. 141, Issue 3579, pp. 435-436
DOI: 10.1126/science.141.3579.435


A basic protein with a molecular weight near 17,000, related serologically to the normal serum γ2-globulins, has been isolated in crystalline form from the urine of a patient with multiple myeloma. Proteins of this size along with the Bence-Jones molecules whose inolecular weight is about 35,000 can provide subunits for studies of the structure of the serum γ-globulins.