Allergic Encephalomyelitis: Rapid Induction without the Aid of Adjuvants

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Science  09 Aug 1963:
Vol. 141, Issue 3580, pp. 529-530
DOI: 10.1126/science.141.3580.529


Rapid production of allergic encephalomyelitis has heretofore required injection of nervous tissue emulsified in immunologic adjuvants. Adjuvants are not required if large doses of a potent nervous-tissue anttigen and a highly susceptible strain of rats are used. Susceptibility was increased in animals inoculated beforehand with pertussis vaccine.