"Microsome" Fraction of Brain: Structural Changes Induced by Ascorbic Acid

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Science  16 Aug 1963:
Vol. 141, Issue 3581, pp. 628-630
DOI: 10.1126/science.141.3581.628


The usual vesicular configuration of membrane fragments in the brain "microsome" fraction is radically altered by treatment with ascorbic acid and adenosine monophosphate. Lightscattering measurements and electron micrographs show that the treated membranes assume predominantly planar forms. This change in structure appears to be contingent upon a continued transport of electrons from ascorbic acid.