Mosaic Histocompatibility of Skin Grafts from Female Mice

Science  16 Aug 1963:
Vol. 141, Issue 3581, pp. 631-633
DOI: 10.1126/science.141.3581.631


The histoincompatibility determined by one or more genes on the X chromosome of the mouse effects a complete rejection of skin of the (C57BL/6 ♀ x BALB/c ♂) F1 hybrid male grafted onto the reciprocal type F1 hybrid male, but only an incomplete rejection of either reciprocal type F1 hybrid female skin, grafted onto the same type of male host. The resulting mosaic survival pattern of the female graft is interpreted as support for the Lyon hypothesis of X-chromosome inactivation.