Lactate Dehydrogenase Variant from Human Blood: Evidence for Molecular Subunits

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Science  16 Aug 1963:
Vol. 141, Issue 3581, pp. 642-643
DOI: 10.1126/science.141.3581.642


A variant of human lactate dehydrogenase is described. The occurrence of lactate dehydrogenase-1, -2, -3, and -4 as five, four, three, and two components, respectively, is interpreted as supporting the hypothesis that LDH isozymes are tetramers formed from various combinations of two types of subunits.