Sex Chromatin Patterns and the Lyon Hypothesis

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Science  16 Aug 1963:
Vol. 141, Issue 3581, pp. 649-650
DOI: 10.1126/science.141.3581.649


Polyploid human cells in culture often have paired sex chromatin masses. They are neither chance juxtapositions of randomly distributed X chromosomes nor manifestations of a propensity for pairing. The pairs are characteristic of the first polyploid interphase. They are thought to reflect the persistent differentiation of X chromosomes, as proposed in the Lyon hypothesis.