Teratogenic Effect of 5-Hydroxytryptamine in Mice

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Science  23 Aug 1963:
Vol. 141, Issue 3582, pp. 717-718
DOI: 10.1126/science.141.3582.717


The subcutaneous injection of a single dose of 5-hydroxytryptamine into pregnant mice produced a large number of fetal abnormalities, mostly of the eyes, limbs, and tail; the skull and central nervous system were also sometimes affected. These effects could result from the action of the drug on placental function and blood supply.