Dialysis Studies in Rats on the Long-Acting Antimalarial CI-501

+ See all authors and affiliations

Science  23 Aug 1963:
Vol. 141, Issue 3582, pp. 723-724
DOI: 10.1126/science.141.3582.723


Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.

Related Content