Dissociation of Homograft Response to Allogeneic versus Xenogeneic Skin Grafts in Irradiated Mice

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Science  30 Aug 1963:
Vol. 141, Issue 3583, pp. 813-814
DOI: 10.1126/science.141.3583.813


Lethally x-irradiated (C3H x DBA/2)F1 mice were protected with syngeneic (isogenic) bone marrow and/ or prior treatment with urethan and skin grafted at various times after irradiation. The ability to reject a first-set xenogeneic (heterologous) skin graft with normal vigor returned within 92 days; the first-set response to allogeneic (homologous) grafts was still impaired 350 days after irradiation.