Acetophenazine and Fighting Behavior in Mice

Science  30 Aug 1963:
Vol. 141, Issue 3583, pp. 830-831
DOI: 10.1126/science.141.3583.830


Assuming fear to be a variable of importance in the inhibition of aggressive behavior, we used acetophenazine to try to facilitate fighting in mature male C57BL mice. Drugged pairs did not differ significantly from controls in fighting latency; however, the time lapse from the first fight to submission and the actual fighting time to submission were significantly longer for drugged pairs. An attempt is made to relate what is known of the action of the drug with research on the neural correlates of aggressive behavior.