Acetylcholine-like Activity in Sciatic Nerve

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Science  06 Sep 1963:
Vol. 141, Issue 3584, pp. 901-902
DOI: 10.1126/science.141.3584.901


Extracts of sciatic nerve exhibit acetylcholine-like activity that is only partly attributable to acetylcholine. The extracts show relatively greater activity on the rectus abdominis muscle of the frog than on the ileum of the guinea pig. To prevent the action of the extract on the frog rectus abdominis muscle, a greater concentration of d-tubocurarine is required than is necessary to prevent the action of known acetylcholine.