Circulating Interferon in Mice after Intravenous Injection of Virus

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Science  13 Sep 1963:
Vol. 141, Issue 3585, pp. 1061-1063
DOI: 10.1126/science.141.3585.1061


Circulating interferon was detectable in mouse serum within 1 hour after the intravenous injection of various types of virus and it reached maximum levels in about 4 hours. Rapidly produced interferon may play a role in the pathogenesis of viral infection and in viral interference.