Actinomycin D Effects in Frog Embryos: Evidence for Sequential Synthesis of DNA-Dependent RNA

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Science  13 Sep 1963:
Vol. 141, Issue 3585, pp. 1063-1064
DOI: 10.1126/science.141.3585.1063


Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.